《英文MSH詞典》MALDI MS
[入口詞] MALDI MS
[主題詞] Spectrometry,Mass,Matrix-Assisted Laser Desorption-Ionization
[英文釋義] A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy,thus inducing a soft disintegration of the sample-matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general,only molecular ions of the analyte molecules are produced,and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis.